Klebsiella pneumoniae is a rod shaped type of bacteria commonly found in the normal flora of the mouth, skin, and intestines.
K. pneumoniae can in turn cause an infection called klebsiella pneumonia. This can provoke lung inflammation and cell death that may produce a thick, bloody, mucoid sputum. This often happens after the bacteria migrate from their normal place of resting to the lower respiratory tract. (For more on this see the questions below)
The KPC superbug arises when the Klebsiella bacteria become resistant to the carbapenem drugs often used to treat them. These drug resistant bacteria are called Carbapenemases. They are active in other bacteria beside Klebsiella and this resistance group are sometimes referred to as Carbapenem Resistant En (CRE)
Different types of KPC exist around the world and are most often seen in hospital patients with compromised immune systems and significant exposure to hospital infections. They have spread around the USA in the last 10 years and often have a foothold in long term care facilities.
They have gained media attention since September 2012 because of the interest in the battle that the National Insitute of Health experienced in uprooting the infection from their state of the art facility and the many deaths that have occurred from one single outbreak. KPC and CRE are considered to be among the most potent threats to public health in the world at this time. They threaten to turn formerly treatable infections into life ending challenges.
See our KPC superbug guide below
- KPC News – Daily Updates
- How is the KPC superbug treated
- What are KPC superbug symptoms
- What is Klebsiella Pneumonia?
- What is the KPC superbug?
The latest news on carbapenemases is below. You can sign up for our weekday newsletter here
- CDC Social Media Tools, Guidelines & Best Practices | Social Media | CDC
- Occurrence of Enterobacter hormaechei carrying blaNDM-1 and blaKPC-2 in China. - PubMed - NCBI
- Copper ions and coordination complexes as novel carbapenem adjuvants. - PubMed - NCBI
- Prevalence of extended-spectrum beta lactamase and carbapenemase-encoding genes in poultry feces from Algeria and Marseille, France. - PubMed - NCBI
- Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014. - PubMed - NCBI
- Combined resistance to multiple antibiotics: a growing problem in the EU
- WHO offers guidance on carbapenem-resistant bacteria | CIDRAP
- Patient Hand Hygiene: The Missing Link - InfectionControl.tips
- The quick loss of carbapenem susceptibility in Pseudomonas aeruginosa at intensive care units. - PubMed - NCBI
- - Document - Structure of Apo- and Monometalated Forms of NDM-1-A Highly Potent Carbapenem-Hydrolyzing Metallo-[beta]-Lactamase
- Emergent Microbial Threats | Nursing
- WHO guidelines for the prevention and control of carbapenem-resistant organisms
- Impact of choice, timing, sequence and combination of broad-spectrum antibiotics on the outcome of allogeneic haematopoietic stem cell transplantation.
- Resistant Infantile Bacterial Conjunctivitis in Egypt: A Microbiology Study.
- California labs commonly use outdated CRE detection practices