Klebsiella pneumoniae is a rod shaped type of bacteria commonly found in the normal flora of the mouth, skin, and intestines.
K. pneumoniae can in turn cause an infection called klebsiella pneumonia. This can provoke lung inflammation and cell death that may produce a thick, bloody, mucoid sputum. This often happens after the bacteria migrate from their normal place of resting to the lower respiratory tract. (For more on this see the questions below)
The KPC superbug arises when the Klebsiella bacteria become resistant to the carbapenem drugs often used to treat them. These drug resistant bacteria are called Carbapenemases. They are active in other bacteria beside Klebsiella and this resistance group are sometimes referred to as Carbapenem Resistant En (CRE)
Different types of KPC exist around the world and are most often seen in hospital patients with compromised immune systems and significant exposure to hospital infections. They have spread around the USA in the last 10 years and often have a foothold in long term care facilities.
They have gained media attention since September 2012 because of the interest in the battle that the National Insitute of Health experienced in uprooting the infection from their state of the art facility and the many deaths that have occurred from one single outbreak. KPC and CRE are considered to be among the most potent threats to public health in the world at this time. They threaten to turn formerly treatable infections into life ending challenges.
See our KPC superbug guide below
- KPC News – Daily Updates
- How is the KPC superbug treated
- What are KPC superbug symptoms
- What is Klebsiella Pneumonia?
- What is the KPC superbug?
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- Activity of Fosfomycin against Extended-Spectrum-β-Lactamase-Producing Uropathogens in Patients in the Community and Hospitalized Patients
- Acinetobacter baumannii Is Dependent on the Type II Secretion System and Its Substrate LipA for Lipid Utilization and In Vivo Fitness
- In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains
- Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
- Characterization of a Carbapenem-Hydrolyzing Enzyme, PoxB, in Pseudomonas aeruginosa PAO1
- Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France -- Birgand et al. 6 (1) -- BMJ Open
- Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics
- Tree-Based Models for Predicting Mortality in Gram-Negative Bacteremia: Avoid Putting the CART before the Horse
- Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1
- Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1 - The Lancet Infectious Diseases
- [Study on genotype and clinical characteristics of infection of carbapenemase-producing Enterobacter cloacae]. - PubMed - NCBI
- Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options. - PubMed - NCBI
- Carbapenem-Resistant Klebsiella pneumoniae: Results of a Laboratory Surveillance Program in an Italian General Hospital (August 2014-January 2015) ... - PubMed - NCBI
- Pharmacokinetics and brain penetration of carbapenems in mice. - PubMed - NCBI
- Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by... - PubMed - NCBI