Klebsiella pneumoniae is a rod shaped type of bacteria commonly found in the normal flora of the mouth, skin, and intestines.
K. pneumoniae can in turn cause an infection called klebsiella pneumonia. This can provoke lung inflammation and cell death that may produce a thick, bloody, mucoid sputum. This often happens after the bacteria migrate from their normal place of resting to the lower respiratory tract. (For more on this see the questions below)
The KPC superbug arises when the Klebsiella bacteria become resistant to the carbapenem drugs often used to treat them. These drug resistant bacteria are called Carbapenemases. They are active in other bacteria beside Klebsiella and this resistance group are sometimes referred to as Carbapenem Resistant En (CRE)
Different types of KPC exist around the world and are most often seen in hospital patients with compromised immune systems and significant exposure to hospital infections. They have spread around the USA in the last 10 years and often have a foothold in long term care facilities.
They have gained media attention since September 2012 because of the interest in the battle that the National Insitute of Health experienced in uprooting the infection from their state of the art facility and the many deaths that have occurred from one single outbreak. KPC and CRE are considered to be among the most potent threats to public health in the world at this time. They threaten to turn formerly treatable infections into life ending challenges.
See our KPC superbug guide below
- KPC News – Daily Updates
- How is the KPC superbug treated
- What are KPC superbug symptoms
- What is Klebsiella Pneumonia?
- What is the KPC superbug?
The latest news on carbapenemases is below. You can sign up for our weekday newsletter here
- Universal Presence of blaNDM-1 Gene in Carbapenem-Resistant Gram-Negative Bacilli in an Indian Hospital in 2015.
- Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from China CRE Network.
- Deep Interviews with Game Changers of Infection Prevention (Part 1) - www.IC.tips
- Healthcare associated bloodstream infections in Polish hospitals: prevalence, epidemiology and microbiology—summary data from the ECDC Point Prevalence Survey of Healthcare Associated Infections 2012–2015 | SpringerLink
- Eurosurveillance | Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014
- Quantifying Hospital-Acquired Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Patients in Dutch Hospitals | Infection Control & Hospital Epidemiology | Cambridge Core
- CPE guidelines galore: ECDC and ACSQH join the party | Reflections on Infection Prevention and Control
- 30-day readmission, antibiotics costs and costs of delay to adequate treatment of Enterobacteriaceae UTI, pneumonia, and sepsis: a retrospective cohort study | Antimicrobial Resistance & Infection Control | Full Text
- One new case of CPE superbug being detected every day
- Detection of blaCTX-M Extended Spectrum Beta-lactamase Producing Salmonella enterica Serotype Typhi in a Tertiary Care Centre. - PubMed - NCBI
- Successful Management of Urosepsis with Ceftriaxone+Sulbactam+EDTA: A Case Report of Penem Sparing Approach. - PubMed - NCBI
- Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection | bioRxiv
- Clinical effect of discordance in empirical treatment of cases with urinary tract infection accompanied by bacteremia.
- Antibiotic resistance status and its costs in hematological patients: A two-year analysis.
- Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters.