Objectives To elucidate the antibacterial efficacy of chemically synthesized and custom-made sulphur nanoparticles SNPs of two different sizes and surface modifications against a number of multidrug-resistant Gram-negative bacilli GNB harbouring the New Delhi metallo-β-lactamase 1 enzyme NDM-1.Methods Antimicrobial susceptibility of the isolates was determined. The strains were evaluated for the presence of carbapenemases, β-lactamases, 16S rRNA methylases and integrons. Chemically synthesized, polyethylene-glycol PEG-stabilized SNPs of 10 nm and custom-made non-capped SNPs of 60 nm were physicochemically characterized and evaluated for their antibacterial efficacy against multidrug-resistant GNB using the agar dilution method ADM and the broth microdilution method BMD. The cytotoxicity of the chemically synthesized SNPs was evaluated with a human-derived hepatoma HepG2 cell line using a WST-1 assay kit.Results All isolates were multidrug-resistant and possessed NDM-1 along with other β-lactamases, 16S rRNA methylases and integron 1. Chemically synthesized PEGylated SNPs showed a bactericidal effect against all tested strains at a concentration between 9.41 and 18.82 mg/L using BMD. The ADM data revealed that SNPs had uniform MICs 18.82 mg/L for all tested strains. On the other hand, custom-made SNPs failed to impart any antibacterial effect at the equivalent concentrations of chemically synthesized SNPs. The WST-1 assay revealed no significant cytotoxicity of the PEGylated SNPs even at the highest concentration 94.08 mg/L.Conclusions To the best of our knowledge, this is the first attempted study to show the effectiveness of nanoparticles against multidrug-resistant GNB harbouring NDM-1.
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NDM Drug Treatment
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Sulphur nanoparticles: an NDM-1 killer?
Objectives To elucidate the antibacterial efficacy of chemically synthesized and custom-made sulphur nanoparticles SNPs of two different sizes and surface [...]
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No NDM-1 drugs before 2016?
The problem of antibiotic resistance is global. Kumarasamy and colleagues traced the NDM-1 to India, with the inference that abuse [...]
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Rib-X Pharmaceuticals working on anti NDM-1 Compound
Rib-X’s RX-04 development program led to the creation of three completely new classes of antibiotics that target a previously unexploited [...]
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Evaluation of antibiotic synergy against NDM-1
Objectives To analyse the in vitro activity of colistin, fosfomycin and tigecycline alone or in combination against enterobacterial NDM-1 producers. [...]
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NDM-1 and Colistin – more concerns over toxicity
The authors present a patient with severe New Delhi metallo–beta–lactamase–1 Escherichia coli infection who developed convulsions rapidly followed by acute [...]
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Making colistin safe for use against NDM-1
A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been [...]
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New guide to colistin dosage
Doctors can now more confidently administer a drug that protects against bacterial superbugs thanks to the development of scientifically-based dosing [...]
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Pessimism about new antibiotics from UK scientist
In the 1990s the pharmaceutical industry abandoned its classical ways of seeking antibiotics and instead adopted a strategy that combined [...]
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Pharmabiz :: Health ministry ready with draft for adding Schedule HX under D&C Act
The Union health ministry is ready with the draft of a national antibiotics policy by inserting a new Schedule called [...]
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Basilea’s antibiotic BAL30072 shows activity against superbugs expressing the NDM-1 resistance factor
New research data on Basilea’s antibacterial compounds was presented in Milan, Italy, at the European Congress of Clinical Microbiology and [...]
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Sulphur nanoparticles: an NDM-1 killer?
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